Diabetes is one of the archaic metabolic diseases which manifested over 3000 years ago in ancient Egyptians as type 1 diabetes which is one of the metabolic genetic disorder.
During the 5th century CE, people of India and different Asiatic countries stated to work on both types of diabetes and they specify that diabetes type 2 is a more common occurrence in the overall population. From the beginning to till date there has no direct/ specific therapeutics recuperation.
Diabetes prevalence has increased by 64 % across India over the quarter-century, according to a November 2017 report by the Indian Council for Medical Research Institute for Health Metrics and Evaluation, both research institutes, and the Public Health Foundation of India, advocacy.
Insulin resistance is the most common metabolic syndrome of present India and the worldwide population. Based on various project U.S. population of 218,000,000 adults in 2007, there are ∼80,000,000 individuals with this metabolic syndrome. At least 50% of Indian will be diabetic in the next 2 decades. “Insulin resistance (IR)” is the conventional accents in medical science. This word has long used frequently in the case of type 2 diabetes.
Due to the modification of insulin receptor or reduction of receptors, or the pancreatic cell’s deformity lose the ability to produce a sufficient amount of required insulin. After all, the mortality rate of chronic diabetic patients is increased due to different pathological ground like myocardial infraction, nephralgic, and neurologic disorder.
Much research pieces of evidence have already proved that stress can induce insulin resistance followed by different life-threatening diseases. Some physiological stress like hormonal imbalance can introduce IR by different chemical substances such as glucocorticoid, steroid, anti-psychotic drugs, statins, and 1st generation protease inhibitors, etc. Some environmental stress like arsenic pollution, pesticides also promote IR conditions. Hypertension is an important stress-induced disease that impaired the renin-angiotensin system followed by any kind of strokes.
There is so much evidence on cortisol, cholesterol, adrenaline, and epinephrine that give a positive induction for the particular metabolic disorder. Alcohol and tobacco both impair normal metabolism and introduce IR and obesity, which can prevail atherosclerosis with time. Adipokines like leptin, adiponectin, resistin, Rbp4, Sfrp5 impaired and promote obesity by IR and increase disease susceptibilities. Obesity and IR both also induce TNF-α, IL6, IL-10, IFN γ, IL-1 like inflammatory& proinflammatory stress marker. Chronic diabetic individuals are much more susceptible to any kind of infection just because of their low immunity.
The Main Causes of this Fastest Growing Pathophysiological Condition are:
- Lack of awareness about diseases.
- Proper medication or therapeutics against this particular metabolic disorder.
- There are no specific, effective, and affordable sets of actions to tackle this disease condition.
- The actual reason for the manifestation of the particular disease that’s maybe the small stress proteins that play a vital mechanistic role in diabetes.
- Introduce some particular immune-boosting foods (fruits, green vegetables, herbs, etc) which give additional supports and strength to fight against infectious diseases.
So, to reduce the metabolic syndrome induced mortality rate throughout the overall population of the whole world and mainly in developing countries, it is very important to increase the proper awareness about this disease and to invent new drugs against this particular disease. This newly invented therapeutic element should be lower in cost and also able to control the main targeting novel molecule like dermcidin, which promotes metabolic syndrome-like condition such as insulin resistance. So, the therapeutic approaches are very important because to control this kind of life-threatening disease which may further induce coronary artery disease like cardiovascular disorder, diabetic nephropathy and also diabetic retinopathy, etc.